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Wang, L., Yang. K., Wang, Q. and Xiao, W. (2022) Genetic analysis of DNA-damage tolerance pathways in Arabidopsis. Plant Cell Rep. (In press) DOI: 10.1007/s00299-022-02942-2. [Text]
Lin, A., Chumala, P., Du, Y., Ma, C., Wei, T., Xu, X., Luo, Y., Katselis, G.S. and Xiao, W. (2022) Transcriptional activation of budding yeast DDI2/3 through chemical modifications of Fzf1. Cell Biol. Toxicol. (In press) DOI: 1007/s10565-022-09745-x. [Text]Bi, T., Niu, X., Qin, C. and Xiao, W. (2021) Genetic and physical interactions between Polη and Rev1 in response to UV-induced DNA damage in mammalian cells. Rep. 11: 21364. [Text]
Kong, M., Li, X., Li, T., Zhao, X., Jin, M., Zhou, X., Gu, H., Mrsa, V., Xiao, W. and Cao, L. (2021) OverexpressingCCW12 in Saccharomyces cerevisiae enables highly efficient ethanol production from lignocellulose hydrolysates. Bioresource Technol. 337: 125487. [Text]
Liu, L., Jin, , Huang, M., Zhu, Y., Yuan, W., Kang, Y., Kong, M., Alim S., Jia, Z., Xu, Z., Xiao, W. and Cao, L. (2021) Engineered polyploid yeast strains enable efficient xylose utilization and ethanol production in corn hydrolysates. Front. Bioeng. Biotechnol. 9: 655272. [Text]Fan, L., Bi, T., Wang, L. and Xiao, W. (2020) DNA-damage tolerance through PCNA ubiquitination and sumoylation. Bioch J. 477: 2655-2677. [Text]
Bai, Z., Wei, M., Li, Z. and Xiao, W. (2020) Drosophila Uev1a is dually required for Ben-dependent DNA-damage response and fly mobility. Cell. Signal. 74: 109719. [Text]
Wu, Z., Andersen, P.L., Moraes, T., McKenna, S.A., Zhang, Y., Zhang, W., Ellison, M.J. and Xiao, W. (2020) Uev1A amino terminus stimulates poly-ubiquitin chain assembly and is required for NF-кB activation. Cell. Signal. 74: 109712. [Text]
Zhu, L., Li, P., Sun, T., Kong, M., Li, X., Ali, S., Liu, W., Fan, S., Qiao, J., Li, S., Peng, L., He, B., Jin, M., Xiao, W. and Cao, L. (2020) Overexpression of SFA1 in engineered Saccharomyces cerevisiae to increase xylose utilization and ethanol production from different lignocellulose hydrolysates. Bioresource Technol 313: 123724. [Text]
Yang, D., Sun, Y., Chen, J., Zhang, Y., Fan, S., Huang, M., Xie, X., Cai, Y., Shang, Y., Gui, T., Sun, L., Hu, J., Dong, J., Yeap, L.-S., Wang, X., Xiao, W. and Meng, F. (2020) REV7 is required for processing AID initiated DNA lesions in activated B cells. Nat. Commun. 11: 2812. [Text]
Wang, F., Li, P., Shao, Y., Li, Y., Zhang, K., Li, M., Wang, R., Zheng, S., Wang, Y., Song, S., Liu, F., Xiao, W. and Li, X. (2020) Site-specific proteolytic cleavage prevents ubiquitination and degradation of human REV3L, the catalytic subunit of DNA polymerase ζ. Nucleic Acids Res. 48: 3619-3637. [Text]
Zang, Y., Gong, Y., Wang, Q., Guo, H. and Xiao, W. (2020) Arabidopsis OTU1, a linkage-specific deubiquitinase, is required for ER-associated protein degradation. Plant J. 101: 141-155. [Text]
Niu, X., Chen, W., Bi, T., Lu M., Qin, Z. and Xiao, W. (2019) Rev1 plays central roles in mammalian DNA-damage tolerance in response to UV irradiation. FEBS J. 286: 2711-2725. [Text]
Li, J., Jia, Y., Lin, A., Hanna, M., Chelico, L., Xiao, W. and Moore, S. (2019) Structure of yeast Ddi2, a highly inducible detoxifying metalloenzyme from S. cerevisiae. J. Biol. Chem. 294: 10674-10685. [Text]
Wang, L., Wen, R., Wang, J., Xiang, D., Wang, Q., Zang, Y., Wang, Z., Huang, S., Li, X., Datla, R., Fobert, P.R., Wang, H., Wei, Y. and Xiao, W. (2019) Arabidopsis UBC13 differentially regulates two programmed cell death pathways in responses to pathogen and low temperature stress. New Phytologist 221: 919-934. [Text]
Lin, A., Zeng, C., Wang, Q., Zhang, W., Li, M., Hanna, M. and Xiao, W. (2018) Utilization of a strongly-inducible DDI2 promoter to control gene expression in Saccharomyces cerevisiae. Front. Microbiol. 9: 2736. [Text]
Rout, M.K., Lee, B.L., Lin, A., Xiao, W. and Spyracopoulos, L. (2018) Active site gate dynamics modulate the catalytic activity of the ubiquitination enzyme E2-25K. Sci. Rep. 8: 7002. [Text]
Wu, Z., Neufeld, H., Torlakovic, E. and Xiao, W. (2018) Uev1A-Ubc13 promotes colorectal cancer metastasis through regulating CXCL1 expression via NF-кB activation. Oncotarget 9: 15952-15967. [Text]
Li, Z., Wang, Y., Li, Y., Zhang, Y., Zhang, Z., Ren, X., Yin, W., Wang, G., Zhu, B., Xiao, W. and Zhang, W. (2018) Ube2s stabilizes β-Catenin through K11-linked polyubiquitination to promote mesendoderm specification and colorectal cancer development. Cell Death & Disease 9: 456. [Text]
Zhao, H., Wang, Q., Liu, C., Shang, Y., Wen, F., Wang, F., Liu, W., Xiao, W. and Li, W. (2018) A role for respiration in regulating meiosis initiation in Saccharomyces cerevisiae. Genetics 208: 1181-1194. [Text]
Qin, Z., Jiang, W., Wang, G., Sun, Y. and Xiao, W. (2018) Linear ubiquitin chain induces apoptosis and inhibits tumor growth. Apoptosis 23: 16-26. [Text]
Zhang, Y., Li, Y., Yang, X., Wang, J., Wang, R., Qian, X., Zhang, W. and Xiao, W. (2018) Uev1A-Ubc13 catalyzes K63-linked ubiquitination of RHBDF2 to promote TACE maturation. Cell. Signal. 42: 155-164. [Text]
Niu, C., Wang, D., Liu, X., Liu, H., Liu, X., Feng, E., Pan, C., Wang, R., Xiao, W., Liu, X., Liu, X., Zhu, L. and Wang, H. (2017) An H-NS family protein, Sfh, regulates acid resistance by inhibition of glutamate decarboxylase expression in Shigella flexneri 2457T. Front. Microbiol. 8: 1923. [Text]
Zhang, W., Zhuang, Y., Zhang, Y., Yang, X., Zhang, H., Wang, G., Yin, W., Wang, R., Zhang, Z. and Xiao, W. (2017) Uev1A facilitates osteosarcoma differentiation by promoting Smurf1-mediated Smad1 ubiquitination and degradation. Cell Death & Diseases 8: e2974. [Text]
Bhat, A., Qin, Z., Wang, G., Chen, W. and Xiao, W. (2017) Rev7, the regulatory subunit of Polζ, undergoes UV-induced and Cul4-dependent degradation. FEBS J. 284: 1790-1803. [Text]
Niu, C., Yang, J., Liu, H., Cui, Y., Xu, H., Wang, R., Liu, X., Feng, E., Wang, D., Pan, C., Xiao, W., Liu, X., Zhu, L. and Wang, H. (2017) Role of the virulence plasmid in acid resistance of Shigella flexneri. Sci. Rep. 7: 46465. [Text]
Qin, Z., Bai, Z., Sun, Y., Niu, X. and Xiao, W. (2016) PCNA-Ub polyubiquitination inhibits cell proliferation and induces cell-cycle checkpoints. Cell Cycle 15: 3390-3401. [Text]
Fan, L. and Xiao, W. (2016) The Pol30-K196 residue plays a critical role in budding yeast DNA postreplication repair through interaction with Rad18. DNA Repair 47: 42-48. [Text]
Guo, H., Wen, R., Wang, Q., Datla, R. and Xiao, W. (2016) Three Brachypodium distachyon Uev1s promote Ubc13-mediated Lys63-linked polyubiquitination and confer different functions. Front. Plant Sci. 7: 1551. [Text]
Yuan, S., Zhang, Z., Zheng, C., Zhao, Z., Wang, Y., Feng, L., Niu, G., Wang, C., Wang, J., Feng, H., Bao, F., Hu, Y., Cao, Y., Ma, L., Wang, H., Kong, D., Xiao, W., Lin, H. and He, Y. (2016) Arabidopsis cryptochrome 1 functions in nitrogen regulation of flowering. Proc. Natl. Acad. Sci. USA 113: 7661-7666. [Text]
Tan, S., Liu, F., Pan, X., Zang, Y., Jin, F., Zu, W., Q, X., Xiao, W. and Yin, L. (2016) CSN6, a subunit of the COP9 signalosome, is involved in early response to iron deficiency in Oryza sativa. Sci. Rep. 6: 25485. [Text]
Xu, X., Lin, A., Zhou, C., Blackwell, S., Zhang, Y., Wang, Z., Feng, Q., Guan, R., Hanna, M.D., Chen, Z. and Xiao, W. (2016) Involvement of budding yeast Rad5 in translesion DNA synthesis through physical interaction with Rev1. Nucleic Acids Res. 44: 5231-5245. [Text]
Wang, J., Zhang, Y., Hou, J., Qian, X., Zhang, H., Zhang, Z., Li, M., Wang, R., Liao, K., Wang, Y., Li, Z., Zhong, D., Wan, P., Dong, L., Liu, F., Wang, X., Wan, Y., Xiao, W. and Zhang, W. (2016) Ube2s regulates Sox2 stability and mouse ES cell maintenance. Cell Death Differ. 23: 393-404. [Text]
Guo, H., Wen, R., Liu, Z., Datla, R. and Xiao, W. (2016) Molecular cloning and functional characterization of two Brachypodium distachyon UBC13 genes whose products promote K63-linked polyubiquitination. Front. Plant Sci. 6:1222. [Text]
Bhat, A., Wu, Z., Maher, V.M., McCormick, J.J. and Xiao, W. (2015) Rev7/Mad2B plays a critical role in the assembly of a functional mitotic spindle. Cell Cycle 14: 3929-3938. [Text]
Li, J., Biss, M., Fu, Y., Xu, X., Moore, S. and Xiao, W. (2015) Two duplicated genes DDI2 and DDI3 in budding yeast encode a cyanamide hydratase and are induced by cyanamide. J. Biol. Chem. 290: 12664-12675. [Text]
Xu, X., Blackwell, S., Lin, A., Li, F., Qin, Z. and Xiao, W. (2015) Error-free DNA-damage tolerance in Saccharomyces cerevisiae. Mutat. Res. - Rev. 764: 43-50. [Text]
Xue, C., Liang, K., Liu, Z., Wen, R. and Xiao, W. (2015) Similarities and differences between Arabidopsis PCNA1 and PCNA2 in complementing the yeast DNA damage tolerance defect. DNA Repair 28: 28-36. [Text]
Rout, M.K., Hodge, C.D., Markin, C.J., Xu, X., Glover, J.N.M., Xiao, W. and Spyracopoulos, L. (2014) Stochastic gate dynamics regulate the catalytic activity of ubiquitination enzymes. J. Am. Chem. Soc. 136: 17446-17458. [Text]
Wen, R., Wang, S., Xiang, D., Venglat, P., Shi, X., Zang, Y., Datla, R., Xiao, W. and Wang, H. (2014) UBC13, an E2 enzyme for Lys63-linked ubiquitination, functions in root development by affecting auxin signaling and Aux/IAA protein stability. Plant J. 80: 424-436. [Text]
Wu, Z., Shen, S., Zhang, Z., Zhang, W. and Xiao, W. (2014) Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-κB mediated matrix metalloproteinase-1 gene regulation. Breast Cancer Res. 16: R75. [Text]
Cao, L., Tang, X., Zhang, X., Zhang, J., Tian, X., Wang, J., Xiong, M. and Xiao, W. (2014) Two-stage transcriptional reprogramming in Saccharomyces cerevisiae for optimizing ethanol production from xylose. Metab. Eng. 24: 150-159. [Text]
Ball, L.G., Xu, X., Blackwell, S., Hanna, M.D., Lambrecht, A.D. and Xiao, W. (2014) The Rad5 helicase activity is dispensable for error-free DNA post-replication repair. DNA Repair 16: 74-83. [Text]
Qin, Z., Lu, M., Xu, X., Hanna, M., Shiomi, N. and Xiao, W. (2013) DNA-damage tolerance mediated by PCNA•Ub fusions in human cells is dependent on Rev1 but not Polη. Nucleic Acids Res. 41: 7356-7369. [Text]
Bhat, A., Andersen, P.L., Qin, Z. and Xiao, W. (2013) The Rev3 subunit of Polζis required for maintaining fragile site stability in human cells. Nucleic Acids Res. 41: 2328-2339. [Text]
Wei, T., Zhang, C., Xu, X., Hanna, M., Zhang, X., Wang, Y., Dai, H. and Xiao, W. (2013) Construction and evaluation of two biosensors based on yeast transcriptional response to genotoxic chemicals. Biosensors and Bioelectronics. 44: 138-145. [Text]
Wen, R., Li, J., Xu, X., Cui, Z. and Xiao, W. (2012) Zebrafish Mms2 promotes K63-linked polyubiquitination and is involved in p53-mediated DNA-damage response. DNA Repair 11: 157-166. [Text]
Xiang, D., Yang, H., Venglat, P., Cao, Y., Wen, R., Ren, M., Stone, S., Wang, E., Wang, H., Xiao, W., Weijers, D., Berleth, T., Laux, T., Selvaraj, G., Datla, R. (2011) POPCORN functions in the auxin pathway to regulate embryonic body plan and meristem organization in Arabidopsis. Plant Cell 23: 4348-4367. [Text]
Andersen, P.L., Xu, F., Ziola, B., McGregor, W.G. and Xiao, W. (2011) Sequential assembly of translesion DNA polymerases at UV-induced DNA damage sites. Mol. Biol. Cell 22: 2373-2383. [Text]
Wang, S., Wen, R., Shi, X., Lambrecht, A., Wang. H. and Xiao, W. (2011) RAD5A and REV3 constitute two alternative mechanisms of DNA damage tolerance in Arabidopsis. DNA Repair 10: 620-628. [Text]
Zhang, M., Zhang, C., Li, J., Hanna, M., Zhang, X., Dai, H. and Xiao, W. (2011) Inactivation of YAP1 enhances sensitivity of the yeast RNR3-lacZ genotoxicity testing system to a broad range of DNA-damaging agents. Toxicol. Sci. 120: 310-321. [Text]
Markin, C.J., Saltibus, L., Kean, M., McKay, R., Xiao, W. and Spyracopoulos, L. (2010) Catalytic proficiency of ubiquitin conjugation enzymes: balancing pKa suppression, entropy, and electrostatics. J. Am. Chem. Soc. 132: 17775-17786. [Text]
Pastushok, L., Hanna, M. and Xiao, W. (2010) Constitutive fusion of ubiquitin to PCNA provides DNA damage tolerance independent of translesion polymerase activities. Nucleic Acids Res. 38: 5047-5058. [Text]
Markin, C.J., Xiao, W. and Spyracopoulos, L. (2010) Mechanism for recognition of polyubiquitin chains: balancing affinity through interplay between multivalent binding and dynamics. J. Am. Chem. Soc. 132: 11247-11258. [Text]
Zhang, M., Hanna, M., Li, J., Butcher, S., Dai, H. and Xiao, W. (2010) Creation of a hyperpermeable yeast strain to genotoxic agents through combined inactivation of PDR and CWP genes. Toxicol. Sci. 113: 401-411. [Text]
Ball, L.G., Zhang, K., Cobb, J.A., Boone, C. and Xiao, W. (2009) The yeast Shu complex couples error-free PRR to homologous recombination. Mol. Microbiol. 73: 89-102. [Text]
Fu, Y., Pastushok, L. and Xiao, W. (2008) DNA damage-induced gene expression in Saccharomyces cerevisiae. FEMS Microbol. Rev. 32: 908-926. [Text]
Huen, M.S.Y., Yuan, J., Yamamoto, M., Akira, S., Ashley, C., Xiao, W. and Chen, J. (2008) Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly. Mol. Cell. Biol. 19: 6104-6112. [Text]
Anderson, H.J., Vonarx, E.J., Pastushok, L., Nakagawa, M., Katafuchi, A., Gruz, P., Di Rubbo, A., Grice, D.M., Osmond, M.J., Sakamoto, A., Nohmi, T., Xiao, W. and Kunz, B.A. (2008) Arabidopsis thaliana Y-family DNA polymerase η catalyses translesion synthesis and interacts functionally with PCNA2. Plant J. 55: 895-908. [Text]
Fu, Y., Zhu, Y. Zhang, K., Yeung, M., Durocher, D. and Xiao, W. (2008) Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp. Cell 133: 601-611. [Text]
Zhang, M., Liang, Y., Zhang, X., Xu, Y., Dai, H. and Xiao, W. (2008) Deletion of yeast CWP genes enhances cell permeability to genotoxic agents. Toxicol. Sci. 103: 68-76. [Text]
Wen, R., Torres-Acosta, J.A., Pastushok, L., Lai, X., Pelzer, L., Wang, H. and Xiao, W. (2008) Arabidopsis UEV1D promotes lysine-63-linked polyubiquitination and is involved in DNA damage response. Plant Cell 20: 213-227. [Text]
Andersen, P.L., Xu, F. and Xiao, W. (2008) Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA. Cell Res. 18: 162-173. [Text]
Barbour, L., Ball, L.G., Zhang, K. and Xiao, W. (2006) DNA damage checkpoints are involved in postreplication repair. Genetics 174: 1789-1800. [Text]
Syed, N.A., Andersen, P.L., Warrington, R.C. and Xiao, W. (2006) Uev1A, a ubiquitin conjugating enzyme variant, inhibits stress-induced apoptosis through NF-κB activation. Apoptosis 11: 2147-2157. [Text]
Fu, Y. and Xiao, W. (2006) Identification and characterization of CRT10 as a novel regulator of Saccharomyces cerevisiae ribonucleotide reductase genes. Nucleic Acids Res. 34: 1876-1883. [Text]
Barbour, L. and Xiao, W. (2006) Mating type regulation of cellular tolerance to DNA damage is specific to the DNA postreplication repair and mutagenesis pathway. Mol. Microbiol. 59: 637-650. [Text]
Andersen, P., Zhou, H., Pastushok, L., Moraes, T., McKenna, S., Ziola, B., Ellison, M.J., Dixit, V.M. and Xiao, W. (2005) Distinct regulation of Ubc13 functions by two Uev proteins Mms2 and Uev1A. J. Cell Biol. 170: 745-755. [Text]
Pastushok, L., Moraes, T.F., Ellison, M.J. and Xiao, W. (2005) A single Mms2 "key" residue insertion into a Ubc13 pocket determines the interface specificity of a human Lys63 ubiquitin conjugation complex. J. Biol. Chem. 280: 17891-17900. [Text]
Zhu, Y and Xiao, W. (2004) Pdr3 is required for DNA damage induction of MAG1 and DDI1 via a bi-directional promoter element. Nucleic Acids Res. 32: 5066-5075. [Text]
Zhou, H., Wertz, I., O'Rourke, K., Ultsch, M., Seshagiri, S., Eby, M., Xiao, W. and Dixit, V.M. (2004) Bcl10 activates the NF-κB pathway through ubiquitination of NEMO. Nature 427: 167-171. [Text]
Hanna, M.D., Meadows, K.L., Chow, B.L., Jinks-Robertson, S., Doetsch, P.W. and Xiao, W. (2004) Involvement of two endonuclease III homologs in the base excision repair for the processing of DNA alkylation damage in Saccharomyces cerevisiae. DNA Repair 3: 51-59 [Text]
Fu, Y. and Xiao, W. (2003) Functional domains required for the Saccharomyces cerevisiae Mus81-Mms4 endonuclease complex formation and nuclear localization. DNA Repair 2: 1435-1447 [Text]
Jia, X. and Xiao, W. (2003) Compromised DNA repair enhances sensitivity of the RNR3-lacZ genotoxic testing system. Toxicol. Sci. 75: 82-88. [Text]
McKenna, S., Moraes, T., Pastushok, L., Ptak, C., Xiao, W., Spyracopoulos, L. and Ellison, M.J. (2003) An NMR based model of the ubiquitin-bound human ubiquitin conjugation complex Mms2/Ubc13: The structural basis for lysine 63 chain catalysis. J. Biol. Chem. 278: 13151-13158. [Text]
Brown, M., Zhu, Y., Hemmingsen, S, and Xiao, W. (2002) Structural and functional conservation of error-free postreplication repair in Schizosaccharomyces pombe. DNA Repair 1: 869-880. [Text]
Li, Z., Xiao, W., McCormick, J.J. and Maher, V.M. (2002) Identification of a protein essential for a major pathway used by human cells to avoid UV-induced DNA damage. Proc. Natl. Acad. Sci. USA 99: 4459-4464. [Text]
Broomfield, S. and Xiao, W. (2002) Suppression of genetic defects within the RAD6 pathway by srs2 is specific for error-free postreplication repair but not for damage induced mutagenesis. Nucleic Acids Res. 30: 732-739. [Text]
McKenna, S., Spyracopoulos, L., Moraes, T., Pastushok, L., Ptak, C., Xiao, W. and Ellison, M.J. (2001) Non-covalent interaction between ubiquitin and the human DNA repair protein Mms2 is required for Ubc13-mediated poly-ubiquitination. J. Biol. Chem. 276: 40120-40126. [Text]
Moraes, T.F., Edwards, R.A., McKenna, S., Pastushok, L., Xiao, W., Glover, J.N.M. and Ellison, M.J. (2001) Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13. Nature Structural Biol. 8: 669-673. [Text]
Xiao, W., Chow, B.L., Broomfield, S. and Hanna, M. (2000) The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free postreplication repair pathways. Genetics 155: 1633-1641. [Text]
Chamankhah, M., Fontanie, T. and Xiao, W. (2000) The Saccharomycescerevisiae mre11(ts) allele confers a separation of DNA repair and telomere maintenance functions. Genetics 155: 569-576. [Text]