Dr. Ed Krol Associate Professor

Academic Background

Welcome to the home page for the research group of Dr. Ed Krol. My lab and office are both situated on the third floor of the Health Sciences building at the University of Saskatchewan.

I accept graduate students from a wide variety of academic backgrounds in the basic sciences including chemistry, biochemistry, biology, toxicology, pharmacology, and physiology to name a few. For more information regarding graduate studies in my group, please visit the graduate studies portion of my website.

For more information contact us at ed.krol@usask.ca or (306) 966-2011.

Academic Positions

2008-present: Associate Professor, College of Pharmacy & Nutrition, University of Saskatchewan

2001-2008:Assistant Professor, College of Pharmacy & Nutrition, University of Saskatchewan

2001-present: Associate Member, Department of Chemistry, University of Saskatchewan

2001-present: Member, Toxicology Graduate Program, University of Saskatchewan

2008-present: Member, Drug Discovery and Development Research Group, University of Saskatchewan

2011-2015: Graduate Chair (Pharmacy)

2000-2001: Assistant Professor, Department of Chemistry, Brandon University

Education

BSc. 1985 (Chemistry) McMaster University

Ph.D. 1993 (Chemistry) Queen's University Supervisor: Gregory R.J. Thatcher

Postdoctoral

1994-1996: University of Illinois-Chicago, College of Pharmacy, Department of Medicinal Chemistry & Pharmacognosy Supervisor: Judy L. Bolton

1996-2000: University of Arizona, College of Pharmacy, Department of Pharmacology & Toxicology Supervisor: Daniel C. Liebler, President Protypia LLC

Societies

Chemical Institute of Canada (1996)

Society of Toxicology of Canada (2000)

American Chemical Society (1995)

International Society for the Study of Xenobiotics (2003)

Research

Research Group

Current Group Members

Postdoctoral
Kevin Allen 2014- 
Ph.D. (Chemistry) University of Victoria (2014)
BSc. (Chemistry) University of Victoria (2008)
Ph.D. Candidates
 
MSc. Candidates  

Nwabufo Chukwunonso Kingsley
MSc. Candidate (Pharmaceutical Sciences) 2017-
BSP (Biochemistry) University of Benin, Nigeria (2015)

Past Group Members

 

Ahmed AlmousaPh.D. (Pharmaceutical Sciences) 2011-2017MSc. (Pharmaceutical Sciences)BSP (Pharmacy)

Kholud Algabbass
MSc.(Pharmaceutical Sciences) 2012-2017
BSP (Pharmacy)
Yunyun Di
Ph.D. (Pharmaceutical Sciences) 2011-2016
Leah McGurn
MSc. (Toxicology) 2013-2016
BSc. (Biochemistry) University of Guelph (2013)
Isaac Asiamah 
Ph.D. (Pharmaceutical Sciences) 2010-2014
BSc. (Chemistry) University of Cape Coast, Ghana (2000)
MSc. (Pharm. Analysis and Quality Control) Kwame Nkrumah University of Science and Technology, Ghana (2003)
Jatinder Mukker
Ph.D. (Pharmaceutical Sciences) University of Saskatchewan 2010-2014
BPharm, Guru Nanak Dev University-Amritsar, India (2009)
Sabia Maini
MSc. (Pharmaceutical Sciences) University of Saskatchewan 2010-2012
BPharm, Guru Nanak Dev University-Amritsar, India (2009)
Chaojie (Jessie) Lin
MSc. (Pharmaceutical Sciences) University of Saskatchewan 2010-2012
BPharm. Eng., Bejing Institute of Technology (2010)
Brian M. Fahlman
Ph.D. (Pharmaceutical Sciences) University of Saskatchewan 2003-2010 
MSc. (Toxicology) University of Saskatchewan (2003) 
BSc. (Biochemistry) University of Regina (1999)
Katie Maloney
MSc. (Pharmaceutical Sciences) University of Saskatchewan 2006-2010
BSc. (Chemistry), University of Saskatchewan (2006)
Jennifer L. Billinsky
Ph.D. (Toxicology) University of Saskatchewan 2002-2009
BSc. (Biochemistry) University of Saskatchewan (2002)
Erin Boyd
MSc. (Toxicology) University of Saskatchewan 2004-2007
BSc. (Biomedical Toxicology) University of Guelph (2004)
Farah Hosseinian 
Ph.D. (Pharmaceutical Sciences) University of Saskatchewan 2001-2006
MSc. (Microbiology and Food Science) University of Saskatchewan (2000)
BSc. (Food Science) Tehran University (1986)
Melanie A. Felmlee 
Ph.D. (Pharmaceutical Sciences), University of Buffalo (2010)
MSc. (Pharmaceutical Sciences) University of Saskatchewan 2002-2005 
BSc. (Biomedical Toxicology) University of Guelph (2001)

Undergrads

Chi Zhang-Chem 483 (2015-2016) 
BSc. (Chemistry) University of Saskatchewan (2016)

Sarah Petriew (2015)
BSc. (Physiology & Pharmacology) University of Saskatchewan (2015)

Heather Hodgson-NSERC USRA (2011, 2012)
BSc. (Biochemistry) University of Saskatchewan (2013)
Krista Dmytryshyn-Chem 483 (2011-2012)
BSc. (Chemistry), University of Saskatchewan (2012)
BEd, University of Saskatchewan (2013)
Manon Hirth-Summer Intern (2010)
BSc. (Toxicology), Universite de Nice-Antipolis (2011)
Margot Klemmer-NSERC USRA (2009)
BSc. (Chemistry), University of Saskatchewan (2011)
MD, University of Saskatchewan (2015)
Andrea Scheler-Chem 483 (2007-2008)
BSc. (Chemistry), University of Saskatchewan (2008)
Katie Maloney-Chem 483 (2005-2006)
BSc. (Chemistry), University of Saskatchewan (2006)
Courtney Wheatley-Summer Intern (2007)
Ph.D., University of Arizona
BS, Iowa Wesleyan College (2008) 
Mary Fraser-CIHR/ Rx&D Summer Studentship (2006)
BSc. (Pharmacy), University of Saskatchewan (2009)
Brian Wong-NSERC USRA (2006)
PharmD., Philadelphia College of Pharmacy
BSc. (Biochemistry), University of Saskatchewan (2009)
Michelle Marcoux-NSERC USRA (2004, 2005)
ND, The Boucher Institute of Naturopathic Medicine
BSc. (Anatomy & Cell Biology), University of Saskatchewan (2006) 
Travis Ancelet-USTEP Research Student (2005)
Ph.D. (Atmospheric Chemistry), Victoria University of Wellington (NZ) (2012) 
MSc. (Chemistry), University of Toronto (2009)
BSc. (Chemistry), University of Saskatchewan (2007) 

Curtis Rieder-Chem 483 (2004-2005)
BSc. (Chemistry), University of Saskatchewan (2005) 
Ph.D. (Chemistry), University of Alberta (2010)
Ken Chalcraft (2004)
Ph.D. (Chemistry), McMaster University (2013)
MSc. (Chemistry), McMaster University (2008)
BSc. (Chemistry), Brandon University (2006)
Melissa Dowd (2002) 
BSc. (Chemistry), Brandon University (2003),
BSc. (Pharmacy) University of Manitoba (2007)

Courses

Publications

Joe Kakish, Kevin J.H. Allen, Troy A. Harkness, Ed S. Krol, Jeremy S. Lee, 2016, Novel Dimer Compounds That Bind alpha-synuclein Can Rescue Cell Growth in a Yeast Model Overexpressing alpha-Synuclein. A Possible Prevention Strategy fo Parkinson's Disease. ACS Chem. NeuroSci, 7 (12) 1671-1680.

Sabia Maini, Brian M. Fahlman and Ed S. Krol, 2015, Flavonols Protect Against UV Radiation-Induced Thymine Dimer Formation in an Artificial Skin Mimic, Journal of Pharmacy and Pharmaceutical Sciences, 18 (4) 600-615.

Isaac Asiamah, Heather L. Hodgson, Katherine Maloney, Ed S. Krol, 2015, Ring Substitution Influences Oxidative Cyclisation and Reactive Metabolite Formation of Nordihydroguaiaretic acid Analogues, Medicinal and Biological Chemistry, 23 (21) 7007-7014.

Jatinder Kaur Mukker, Ravi S. Singh, Alister D. Muir, Ed S. Krol and Jane Alcorn, 2015, Comparative Pharmacokinetics of Purified Flaxseed and Associated Mammalian Lignans in Male Wistar Rats, British Journal of Nutrition, 113 (5) 749-757.

Jatinder Kaur Mukker, Deborah Michel, Alister D. Muir, Ed S. Krol and Jane Alcorn, 2014. Permeability and Conjugative Metabolism of Flaxseed Lignans by Caco-2 Human Intestinal Cells. Journal of Natural Products, 77(1) 29-34.

Chaojie Lin, Ed S Krol and Jane Alcorn, 2013. The Comparison of Rat and Human Intestinal and Hepatic Glucuronidation of Enterolactone Derived from Flaxseed Lignans. The Natural Products Journal, 3 (3) 159-171.

Natasha Vetter, David Langill, Shazia Anjum, Julie Boisvert, Rajendra Jagdhane, Egiroh Omene, Hongyan Zheng, Karin van Straaten, , Isaac Asiamah, Ed S. Krol, David Sanders, David Palmer, 2013. A Previously-Unrecognized Kanosamine Biosynthesis Pathway in Bacillus subtilis. Journal of the American Chemical Society, 135(16), 5970-5973.

Sabia Maini, Heather L. Hodgson and Ed S. Krol, 2012. The UVA and aqueous stability of flavonoids is dependent on B-ring substitution. Journal of Agricultural and Food Chemistry. 60(28), 6966-6976.

Ed S. Krol and Lisa M. Krol, 2012. Referencing and Citation for Graduate Students: Gain Without Pain. Collected Essays on Learning and Teaching. 5, 65-68.
 
Ed S. Krol, 2011. Metabolic Detoxication Pathways for Sterigmatocystin in Primary Tracheal Epithelial Cells: Structural identification of glutathione adducts, Chemical Research in Toxicology, 24(9),1339-1340 Letter to the Editor
 
Brian M. Fahlman and Ed S. Krol, 2009. UVA and UVB Radiation-Induced Oxidation Products of Quercetin, Journal of Photochemistry and Photobiology B: Biology, 97, 123-131.   
 
Brian M. Fahlman and Ed S. Krol, 2009. Inhibition of UVA and UVB radiation-induced lipid oxidation by quercetin, Journal of Agricultural and Food Chemistry, 57 (12), 5301-5305.
 
Lifeng Chen, Katie Maloney, Ed S. Krol, Anne E. Desjardins and Jian Yang, 2009. Cloning, Overexpression, Purification and Characterization of the Maleylacetate Reductase (PcpE) from Sphingobium chlorophenolicum Strain ATCC 53874, Current Microbiology, 58 (6), 599-603.
 
Melanie A. Felmlee, Gloria Woo, Elmer Simko, Ed S. Krol, Alister D. Muir and Jane Alcorn, 2009. Effects of the flaxseed lignans secoisolariciresinol diglucoside and its aglycone on serum and hepatic lipids in hyperlipidemic rats. British Journal of Nutrition, 102 (3), 361-369.
 
Jennifer L. Billinsky,and Ed S. Krol, 2008. Nordihydroguaiaretic Acid Oxidation Produces a Schisandrin-like Dibenzocyclooctadiene Lignan, Journal of Natural Products71 (9), 1612-1615.

Jennifer L. Billinsky, Michelle R. Marcoux and Ed S. Krol, 2007. Oxidation of Nordihydroguaiaretic Acid, Chemical Research in Toxicology, 20 (9), 1352-1358.

Farah S. Hosseinian, Alister D. Muir, Neil D. Westcott and Ed S. Krol, 2007.  AAPH-Mediated Antioxidant Reactions of Secoisolariciresinol and SDG.  Organic and Biomolecular Chemistry, 5 (4), 644-654.

Farah S. Hosseinian, Alister D. Muir, Neil D. Westcott and Ed S. Krol, 2006.  Antioxidant Capacity of Flaxseed Lignans in Two Model Systems.  Journal of the American Oil Chemists Society, 83 (10), 835-840.

Graduate Studies

I accept graduate students from a wide variety of academic backgrounds in the basic sciences including chemistry, biochemistry, biology, toxicology, pharmacology and physiology to name a few. Students with nationally competitive scholarships such as NSERC or CIHR receive tuition waivers from the College.

As a graduate student in my lab you would receive training in several of the following areas:

  • drug metabolism
  • analytical method development
  • product purification andidentification
  • animal studies
  • organic synthesis
  • physical-organic chemistry
A majority of the work in my lab requires the use of HPLC. We have several instruments including a Waters Alliance system, shown here.
The Alliance system was purchased with funds from CFI

We also have access to the Saskatchewan Structural Sciences Centre (SSSC) which is conveniently located in the Thorvaldson building. We utilize the NMR and MS facilities in the SSSC extensively.

My research group holds group meetings and literature review meetings on alternate weeks throughout the year.

I am an Associate member of the Department of Chemistry and a member of the Toxicology Graduate Program. Therefore, students may also join my research group through these programs.

For information regarding application for graduate studies in the College of Pharmacy & Nutrition please click here.