Publications

Carolina Reis Zambom, Gabriel Dalio Bernardes da Silva, Fauller Henrique da Fonseca, Gabriela Vieira Silva Zolin, Mariana de Melo Faceto Portella, Lina Maria Marin, Edson Crusca, Ed S. Krol, Walter L. Siqueira, Saulo Santesso Garrido, 2025. Reducing functional domain of Histatin 5 improves antifungal activity and prevents proteolytic degradation. Microorganisms, 13(5), 1091 doi.org/10.3390/microorganisms13051091

Melissa Mejia Gutierrez, Brigitte Moser, Haixia Zhang, Paulos Chumala, George S. Katselis David R.J. Palmer, Ed S. Krol, 2024. Caffeine and nicotine with N-substituted diazirine photoaffinity labels form adducts at Tyrosine-39 of alpha-synuclein. ACS Chemical Neurosciences, 16 (8), 1539-1549. doi: 10.1021/acschemneuro.5c00074

Ed S. Krol, 2024. Integration of medicinal chemistry in therapeutic decision-making: A way forward? Currents in Pharmacy Teaching and Learning, 17, 102229. doi.org/10.1016/j.cptl.2024.102229

Elisabet Jakova, Omozojie P. Aigbogun, Mohamed Taha Moutaoufik, Kevin J.H. Allen, Omer Munir, Devin Brown, Changiz Taghibiglou, Mohan Babu, Chris P. Phenix, Ed S. Krol, Francisco S. Cayabyab, 2024. The bifunctional dimer caffeine-indan attenuates alpha-synuclein misfolding, neurodegeneration and behavioural deficits after chronic stimulation of adenosine A1 receptors. International Journal of Molecular Sciences, 25 (17), 9386. doi.org/103390/ijms25179386.

Phillip Ankley, Francisco da Silva, David Montgomery, Matthew Schultz, Ed S. Krol, Markus Hecker, Markus Brinkmann, 2024. Biotransformation of 6PPD-quinone In Vitro Using RTL-W1 Cell Line. Environmental Science & Technology Letters, 11 (7), 687-693. doi.org/10.1021/acs.estlett.4c00342.

Ed S. Krol, Carlos Velazquez-Martinez, Tannis M. Jurgens and Simon P. Albon, 20204. Medicinal chemistry curriculum and pedagogical practices at Canadian pharmacy schools: Towards standardization of practice. Currents in Pharmacy Teaching and Learning, 16, 102095. doi.org/10.1016/j.cptl.2024.04.011

Omozojie P. Aigbogun, Ed S. Krol, Christopher P. Phenix, Eric Price, 2023. The Chemistry of Creating Chemically Programmed Antibodies (cPAbs): Site-Specific Bioconjugation of Small Molecules. Molecular Pharmaceutics, 20 (2), 853-874. doi: 10.1021/acs.molpharmaceut.2c00821

Gabriel Bernardes, Ed S. Krol, 2023. In vitro Hepatic Metabolism of the Natural Product Quebecol. Xenobiotica, 53 (1), 1-11. doi: 10.1080/00498254.2023.2180691

Gabriel Bernardes, Omer Munir, Ed S. Krol, 2022. The effect of diphenylethane side-chain substituents on dibenzocyclohexadiene formation and their inhibition of alpha-synuclein in vitro. Bioorganic and Medicinal Chemistry, 78, 116147. doi.org/10.1016/j.bmc.2002.117147

Omozojie P. Aigbogun, Chukwunonso K. Nwabufo, Madeline N. Owens, Kevin J.H. Allen, Jeremy S. Lee, Christopher P. Phenix and Ed S. Krol, 2022. An HPLC-UV validated bioanalytical method for measurement of in vitro Phase 1 kinetics of α-synuclein binding bifunctional compounds. Xenobiotica, 52 (8), 916-927. doi: 10.1080/00498254.2022.2140315 Xenobiotica top ten most read in 2022 with 738 downloads.

Raj Rai, Saniya Alwani, Behlol Khan, Raja Vishwas, Stephanie Vuong, Ed S. Krol, Humphrey Fonge, Ildiko Badea, 2023. Biodistribution of nanodiamonds is determined by surface functionalization. Diamonds and Related Materials, 137, 110071. doi:10.1016/j.diamond.2023.110071

Chukwunonso K. Nwabufo, Omozojie P. Aigbogun, Kevin J.H. Allen, Madeline N. Owens, Jeremy S. Lee, Christopher P. Phenix and Ed S. Krol, 2021. Employing in vitro Metabolism to Guide Design of F-Labelled PET Probes of Novel alpha-Synuclein Binding Bifunctional Compounds. Xenobiotica, 50 (8), 885-900. doi.org/10.1080/00498254.2021.1943566

Wei Jin, Randy Purves, Ed Krol, Ildiko Badea, Anas El-Aneed, 2020. Mass Spectrometric Detection and Characterization of Metabolites of Gemini Surfactants Used as Gene Delivery Vectors. Journal of the American Society of Mass Spectrometry, 31 (2), 366-378. doi: 10.1021/jasms.9b00004

Ellen K. Wasan, Jinying Rita Zhao, Munawar Ali Mohammed, Jaweria Syeda, Jacqueline Cawthray, Joshua Poteet, Tatiana Orlowski, Chi Zhang, Brian M. Fahlman, Amanda Bunyamin, Kevin Soulsbury, Ed S. Krol, 2019. Development of a UV-Stabilized Topical Formulation of NIfedipine for the Treatment of Raynaud Phenomenom and Chilblains. Pharmaceutics, 11 (11), doi: 10.3390/pharmaceutics11110594

Chukwunonso K. Nwabufo, Anas El-Aneed, Ed S. Krol, 2019. Tandem Mass Spectrometric Analysis of Novel Caffeine Scaffold-Based Bifunctional Compounds for Parkinson’s disease, Rapid Communications in Mass Spectrometry, 33 (23), 1792-1803. doi: 10.1002/rcm.8540

Malcolm J. Daniels, J. Brucker Nourse, Hanna Kim, Valerio Sainati, Marco Schiavina, Maria Grazia Murrali, Buyan Pan, John J. Ferrie, Conor M. Haney, Rani Moons, Neal S. Gould, Antonio Natalello, Rita Grandori, Frank Sobbot, E. James Petersson, Elizabeth Rhoades, Roberta Pierattelli, Isabella Felli, Vladimir N. Uversky, Kim A. Caldwell, Guy A. Caldwell, Ed S. Krol, Harry Ischiropoulos, 2019, Cyclized NDGA modifies dynamic alpha-synuclein monomers preventing aggregation and toxicity, Scientific Reports, doi: 10.1038/s41598-39480-z

Ed S. Krol, Roy Thomas Dobson and Kunmi Adesina, 2019, The Association between Academic Success in a Professional Pharmacy Program and Performance in BSP and Pharm D Prerequisites at the University of Saskatchewan. American Journal of Pharmaceutical Education, 83 (1) Article 6491.

Isaac Asiamah, Ed S. Krol, 2018, Quadrupole Linear ion-trap Mass Spectrometry Studies on Glutathione Conjugates of Nordihydroguaiaretic acid (NDGA) Analogues Reveals Phenol-type Analogues are Without Reactive Metabolite-mediated Toxic Liability, Cogent Chem., doi: 10.1080/23312009.2018.1562858.

Ahmed A. Almousa, Francois Meurens, Ed S. Krol, Jane Alcorn, 2018, Linoorbitides and Enterolactone Mitigate Inflammation-induced Oxidative Stress and Loss of Intestinal Epithelial Barrier Integrity, Int. Immunopharmacol., 64, 42-51.

Lifeng Chen, Ed Krol, Meena Sakharkar, Haseeb Khan, Abdullah Alhomic and Jian Yang, 2017, Residues His172 and Lys238 are Essential for the Catalytic Activity of the Maleylacetate Reductase from Sphingobium chlorophenolicum Strain L-1, Scientific Reports, doi:10.1038/s41598-017-18475-8

Yunyun Di, Shanal DeSilva, Ed S. Krol and Jane Alcorn, 2017, Flaxseed Lignans Enhance the Cytotoxicity of Chemotherapeutic Agents against Breast Cancer Cell Lines MDA-MB-231 and SKBR3, Nutrition and Cancer, 70 (2) 306-315.

David F. Blackburn, Munpreet Gill, Ed S. Krol, Jeff Taylor, 2017, Natural Health Products and Community Pharmacy – Remove the mysticism not the product. Journal of Pharmacy Practice, doi: 10.1177/0897190017708074

Yunyun Di, Shaoping Ji, Philipp Wolf, Ed S. Krol, Jane Alcorn, 2017, Enterolactone Glucuronide and beta-Glucuronidase in Antibody Directed Enzyme Prodrug Therapy for Targeted Prostate Cancer Cell Treatment. AAPS PharmSciTech, doi: 10.1208/s12249-017-0721-5

Joe Kakish, Kevin J.H. Allen, Troy A. Harkness, Ed S. Krol, Jeremy S. Lee, 2016, Novel Dimer Compounds That Bind alpha-synuclein Can Rescue Cell Growth in a Yeast Model Overexpressing alpha-Synuclein. A Possible Prevention Strategy fo Parkinson's Disease. ACS Chem. NeuroSci, 7 (12) 1671-1680.

Sabia Maini, Brian M. Fahlman and Ed S. Krol, 2015, Flavonols Protect Against UV Radiation-Induced Thymine Dimer Formation in an Artificial Skin Mimic, Journal of Pharmacy and Pharmaceutical Sciences, 18 (4) 600-615.

Isaac Asiamah, Heather L. Hodgson, Katherine Maloney, Ed S. Krol, 2015, Ring Substitution Influences Oxidative Cyclisation and Reactive Metabolite Formation of Nordihydroguaiaretic acid Analogues, Medicinal and Biological Chemistry, 23 (21) 7007-7014.

Jatinder Kaur Mukker, Ravi S. Singh, Alister D. Muir, Ed S. Krol and Jane Alcorn, 2015, Comparative Pharmacokinetics of Purified Flaxseed and Associated Mammalian Lignans in Male Wistar Rats, British Journal of Nutrition, 113 (5) 749-757.

Jatinder Kaur Mukker, Deborah Michel, Alister D. Muir, Ed S. Krol and Jane Alcorn, 2014. Permeability and Conjugative Metabolism of Flaxseed Lignans by Caco-2 Human Intestinal Cells. Journal of Natural Products, 77(1) 29-34.

Chaojie Lin, Ed S Krol and Jane Alcorn, 2013. The Comparison of Rat and Human Intestinal and Hepatic Glucuronidation of Enterolactone Derived from Flaxseed Lignans. The Natural Products Journal, 3 (3) 159-171.

Natasha Vetter, David Langill, Shazia Anjum, Julie Boisvert, Rajendra Jagdhane, Egiroh Omene, Hongyan Zheng, Karin van Straaten, , Isaac Asiamah, Ed S. Krol, David Sanders, David Palmer, 2013. A Previously-Unrecognized Kanosamine Biosynthesis Pathway in Bacillus subtilis. Journal of the American Chemical Society, 135(16), 5970-5973.

Sabia Maini, Heather L. Hodgson and Ed S. Krol, 2012. The UVA and aqueous stability of flavonoids is dependent on B-ring substitution. Journal of Agricultural and Food Chemistry. 60(28), 6966-6976.

Ed S. Krol and Lisa M. Krol, 2012. Referencing and Citation for Graduate Students: Gain Without Pain. Collected Essays on Learning and Teaching. 5, 65-68.