Picture of Dr. Yen-Han Lin

Dr. Yen-Han Lin PhD, PEng Professor Department of Chemical and Biological Engineering

B.Sc. (National Taiwan Institute of Technology) 1984 Ph.D. (Rensselaer Polytechnic Institute) 1995

57 Campus Drive, Saskatoon, SK S7K 5A9, Canada

Research Area(s)

  • Yeast physiology and metabolic pathway analysis
  • Applied bioinformatics and protein-protein interaction network
  • Ethanol fermentation and bioprocess development


List of recent refereed articles (bold indicates students and/or HQP, and "*" indicates corresponding author)

  1. S. Shen, Y.-H. Lin, and C. Liu "Real-time microbial growth monitoring by combining microbial fuel cell based device with modified Nernst equation", Canadian Journal of Chemical Engineering, https://doi.org/10.1002/cjce.25114,2023.
  2. P. Teng, and Y.-H. Lin "Designing a novel portable oxidation-reduction potential and microbial fuel cell-based sensor to monitor microbial growth", Canadian Journal of Chemical Engineering, https://doi.org/10.1002/cjce.25044,2023. 
  3. G. Hassemer, L. Nascimento, Y.-H. Lin, C. Steffans, A. Junges, and E. Valduga "Influence of redox potential on the accumulation of poly(3-hydroxybutyrate) by Bacillus megaterium", Bioprocess and Biosystems Engineering, https://link.springer.com/article/10.1007/s00449-023-02889-y, 2023.
  4. Y. Wu and Y.-H. Lin* "Fermentation redox potential control on the 1,3-propanediol production by Lactobacillus panis PM1", Process Biochemistry, 114:139-146,2022.
  5. J. Guo, Y. Wu, T. Tanaka and Y.-H. Lin* “Development of redox potential-driven fermentation process for recombinant protein expression”, Biotechnology Letters, 43:99-103,2021.
  6. S. Feng and Y.-H. Lin* “Development of dissolved carbon dioxide-driven-and-controlled repeated batch fermentation process for ethanol production”, Canadian Journal of Chemical Engineering, https://doi.org/10.1002/cjce.23822, 2020.
  7. X. Huang, S. Yang and Y.-H. Lin* “Biodegradation of catechol by Pseudomonas fluorescens isolated from petroleum-impacted soil”, Canadian Journal of Chemical Engineering, https://doi.org/10.1002/cjce.23859, 2020.
  8. Y. Zhang and Y.-H. Lin* “Metabolic flux analysis of Saccharomyces cerevisiae during redox potential-controlled very-high-gravity ethanol fermentation”, Biotechnology and Applied Biochemistry, 2019.
  9. X. Huang and Y.-H. Lin* “Reconstruction and analysis of a three-compartment genome-scale metabolic model for Pseudomonas fluorescens”, Biotechnology and Applied Biochemistry, 2019.
  10. C. Liu, J. Qin, and Y.-H. Lin* “Fermentation and redox pote ntial”, In: Angela Jozala (ed.), Chapter 2, Fermentation Processes, 2017.
  11. A. Thani, Y.-H. Lin*, P. Laopaiboon, L. Laopaiboon* “Variation of fermentation redox potential during cell-recycling continuous ethanol operation”, J Biotechnology, 239:68-75, 2016.
  12. C. Liu, X. Hao, Y.-H. Lin*, and F. Bai* “Redox potential driven aeration during very-high-gravity ethanol fermentation by using flocculating yeast”, Scientific Reports, 6:25763, 2016.
  13. C. Liu, L. Liu, Y.-H. Lin*, and F. Bai* “Kinetic modeling for redox potential-controlled repeated batch ethanol fermentation using flocculating yeast”, Process Biochemistry, 50:1-7, 2015.
  14. S. Feng and Y.-H. Lin* “Ethanol fermentation under dissolved carbon dioxide control”, Energy Procedia, 61:2719-2732, 2014.
  15. Y.-H. Lin* and C. Liu “Process design for very-high-gravity fermentation”, Energy Procedia, 61:2725-2728, 2014.
  16. N. Khongsay, Y.-H. Lin*, P. Laopaiboon, and K. Laopaiboon* "Improvement of very-high-gravity fermentation from sweet sorhgum juice by controlling fermentation redox potential", J Taiwan Institute of Chemical Engineers, 45:302-307, 2014.
  17. C. Liu, Y.-H. Lin* and F. Bai "Global gene expression analysis of Saccharomyces cerevisiae grown under redox potential-controlled very-high-gravity conditions", Biotechnology J, 8:1332-1340, 2013.
  18. Y. Lin, W. Lee, K. Duan, and Y.-H. Lin "Ethanol production by simultaneous saccharification and fermentation in rotary drum reactor using thermotolerant Kluveromyces marxianus", Applied Energy, 105:389-394, 2013.
  19. C. Liu, C. Xue, Y.-H. Lin* and F. Bai* "Redox potential control and applications in microaerobic and anaerobic fermentations", Biotechnology Advances, 31(2):257-265, 2013.
  20. C. Liu, N. Wang, Y.-H. Lin* and F. Bai* "Very high gravity ethanol fermentation by flocculating yeast under redox potential-controlled conditions", Biotechnology for Biofuels, 5(61):1-7, 2012.
  21. S. Srinivasan, S. Feng and Y.-H. Lin* "Dissolved carbon dioxide concentration profiles during very-high-gravity ethanol fermentation", Biochemical Engineering J, 69:41-47, 2012.
  22. F. Yu and Y.-H. Lin* "Techno-economic evaluation of redox potential-controlled ethanol fermentation processes", J Taiwan Institute of Chemical Engineers, 43(6):813-819, 2012.
  23. S. Feng, S. Srinivasan and Y.-H. Lin* "Redox potential-driven repeated batch ethanol fermentation under very-high-gravity conditions", Process Biochemistry, 47(3):523-527, 2012.
  24. C. Liu, Y.-H. Lin* and F. Bai "Ageing vessel design and optimization for continuous very-high-gravity ethanol fermentation processes", Process Biochemistry, 47(1):57-61, 2012.
  25. W.M. Ingledew and Y.-H. Lin "Ethanol from starch-based feedstocks", In: Moo-Young M, (ed.) Comprehensive Biotechnology, 2nd Edition, 3:37-49, 2011, Elsevier.
  26. Y.-H. Lin*, J. Chang, K. Duan and P. Chang "Development of t50 and its application to evaluate very-high-gravity fermentation", J Bioscience and Bioengineering, 112(4):388-394, 2011.
  27. C. Liu, Y.-H. Lin* and F. Bai "A kinetic growth model for Saccharomyces cerevisiae grown under redox potential-controlled very-high-gravity environment", Biochemical Engineering J, 56(1-2):63-68, 2011.
  28. C. Liu, Y.-H. Lin* and F. Bai "Development of redox potential-controlled schemes for very-high-gravity fermentation", J Biotechnology, 153(1-2):42-47, 2011.
  29. Y.-H. Lin*, W. Chien, K. Duan and P. Chang "Effect of aeration timing and interval during very-high-gravity ethanol fermentation", Process Biochemistry, 46(4):1025-1028, 2011.
  30. C. Liu, Y.-H. Lin* and F. Bai "Ageing vessel configuration for continuous redox potential-controlled very-high-gravity fermentation", J Bioscience and Bioengineering, 111(1):61-66, 2011.
  31. J. Chang, Y.-H. Lin*, L. Huang and K. Duan* "The effect of fermentation configuration and FAN supplementation on ethanol production from sorghum grains under very-high-gravity fermentation", J Taiwan Institute of Chemical Engineers, 42(1):1-4, 2011.
  32. Y.-H. Lin*, W. Chien and K. Duan "Correlations between reduction-oxidation potential profiles and growth patterns of Saccharomyces cerevisiae during very-high-gravity fermentation", Process Biochemistry, 45(5):765-770, 2010.
  33. Y. Zhao and Y.-H. Lin* "Whole-cell protein identification using the concept of unique peptides", Genomics, Proteomics & Bioinformatics, 8(1):33-41, 2010.
  34. K. Theerarattananoon, Y.-H. Lin* and D.-Y. Peng "Metabolic heat evolution of Saccharomyces cerevisiae grown under very-high-gravity conditions", Process Biochemistry, 43(11):1253-1258, 2008.
  35. M.A. Mahdavi and Y.-H. Lin* "False positive reduction in protein-protein interaction predictions using gene ontology annotations", BMC Bioinformatics, 8:262, 2007.
  36. M.A. Mahdavi and Y.-H. Lin* "Prediction of protein-protein interaction using the protein signature profiling", Genomics, Proteomics & Bioinformatics, 5(3-4),177-186, 2007.
  37. T. Rajarathinam and Y.-H. Lin* "Topological properties of protein-protein and metabolic interaction network of Drosophila melanogaster", Genomics, Proteomics & Bioinformatics, 4(2):80-89, 2006.
  38. Y. Zhao and Y.-H. Lin* "The development of an algorithm for the mass spectral interpretation of phosphoproteins", Proteomics, 5(4):843-845, 2005.
  39. Y. Zhao and Y.-H. Lin"A proteomic tool for the protein identification from the tandem mass spectral data", Proteomics, 5(4):853-855, 2005.
  40. Y. Zhao and Y.-H. Lin* "The growth of Saccharomyces cerevisiae in a chemostat under high glucose conditions", Biotechnology Letters, 25(14):1151-1154, 2003.
  41. L. C. Ong and Y.-H. Lin* "Metabolite profiles and growth characteristics of Rhizobium meliloti cultivated at different growth rates", Biotechnology Progress, 19(3):714-719, 2003.
  42. Y.-H. Lin*, D. Bayrock and W. M. Ingledew, "Evaluation of Saccharomyces cerevisiae grown in a multistage chemostat environment under increasing levels of glucose", Biotechnology Letters, 24(6):449-453, 2002.
  43. Y Zhao and Y-H Lin* "Flux distribution and partitioning in Corynebacterium glutamicum grown at different specific growth rates", Process Biochemistry, 37:775-785, 2002.
  44. Y. Zhao and Y.-H. Lin* "Distribution of ATP and reducing equivalents in Corynebacterium glutamicum during amino acid resolution", Process Biochemistry, 37:1455-1461, 2002.
  45. Y.-H. Lin*, D. Bayrock and W. M. Ingledew, "Metabolic flux variation of Saccharomyces cerevisiae cultivated in a multistage CSTR fermentation environment", Biotechnology Progress, 17(6):1055-1060, 2001.